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Dr Hall's research is into nucleic acid structure and function. He is an experienced X-ray crystallographer and user of Diamond Light Source, with over 65 structures published in the Protein Data Bank, who also uses solution-phase techniques, including UV/visible absorbance and circular dichroism (B23 at DLS), to cross-validate crystal structure with solution behaviour. He has a particular interest in the mechanisms of nucleic acid damage, the development and exploitation of non-canonical nucleic acid structures for therapeutic applications and DNA-ligand interactions.

Dr Hall is also interested in pedagogic and educational research, with a particular interest in using virtual reality methods within teaching. He has collaborated to develop, deploy and evaluate VR-based teaching materials on a class scale within both chemistry-focussed and clinical teaching.